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Head-To-Head Study Shows More Elderly Patients With Community ... - PR Newswire (press release)

CAPRIE first clinical study to compare fluoroquinolones in elderly population with community-acquired Pneumonia KENILWORTH, N.J., Jan. 24 /PRNewswire-FirstCall/ -- Significantly More elderly patients treated with AVELOX(R) (moxifloxacin HCl) for community-acquired Pneumonia (CAP) recovered at days 3 to 5 of a 7 to 14 day course of treatment than those treated with LEVAQUIN (levofloxacin), according to results of a clinical study published in the current issue of Clinical Infectious Diseases.(1) The first comparative, head-to-head evaluation of two fluoroquinolone antibiotics in hospitalized elderly CAP patients showed that 97.9 percent of AVELOX patients recovered at days 3 to 5 compared to 90.0 percent of LEVAQUIN patients (P=0.01). There Was no significant difference between the two treatments with regard to cardiac safety, the primary endpoint of the study, or clinical cure rates 5 to 21 days after the end of treatment, the primary efficacy endpoint. Additional analyses examined cure rates across CAP severity and age subgroups, including mild to moderate CAP, severe CAP, CAP in patients 65-74 years of age, and CAP in patients 75 years of age or older. Patients treated with AVELOX achieved a cure rate of 90 percent or greater in all CAP severity and age subgroups. The rates of investigator-reported - More available

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