A paper by Swedish scientist Per Svenningsson and colleagues in last month's Science provides a novel, key insight into the mood disorder depression. Clinical depression affects 14.8 million American adults and millions of others experience temporary stress-related depression in times of hardship. Despite this, the etiology of depression remains largely unknown. In the late 1960s, a link was Made between the neurotransmitter serotonin and depression. The strongest evidence for this link is that development of drugs designed to enrich the synapse with serotonin has led to successful treatment of depression and other psychiatric disorders. These drugs, called selective serotonin-reuptake inhibitors (SSRIs-Common names Prozac, Zoloft, Celexa, Lexapro, Luvox, and Paxil), find themselves among the most prescribed drugs in the country and represent One of the most lucrative drug markets (Zoloft alone brings in $3 billion/year in profits). Unfortunately, approximately 30 percent of depressed patients suffer from treatment-resistant depression, for which SSRIs fail to alleviate symptoms. In the last 40 years, we've learned very little else about the cause of depression and its symptoms. In an elegant set of experiments, Svenningsson and colleagues take us One step further in elucidating the biological mechanism(s) responsible for depression symptoms. The article states that a - More available
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