Although most reactions to the vaccinia virus are mild, the vaccine can cause serious and even life-threatening complications in individuals with weakened immune systems or skin conditions such as Eczema, in infants younger than 12 months and in pregnant women. Health Care providers currently treat smallpox vaccine complications with anti-vaccinia Immune Globulin (VIG) — pooled antibodies taken from the blood of individuals immunized with the smallpox vaccine. However, VIG is in short supply since the United States discontinued its public smallpox vaccination program in 1972.
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