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Latest Marc Gene News
Swiss researchers develop all-in-one remote control gene ... - EurekAlert (press release)
The researchers have combined several gene manipulation techniques and incorporated them into a single lentiviral vector – a gene delivery system partly derived from HIV. When injected into living cells – either in vitro or in vivo – the genetic material aboard the lentiviral vector joins the genetic material in the nucleus of the cell, causing the cell to express the protein encoded by the new gene. This versatile package can also carry bits of RNA that stop the cell from expressing One of its own genes, by way of RNA interference. But the cargo that makes this tool really novel and exciting is a Fusion protein that acts as a kind of remote control. By administering an antibiotic, the genetic manipulation – either the transgenic material introduced by the lentivirus, or the gene silencing via RNA interference--can be switched on or off at will.
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